toll like receptor 2 and 4 expression in peripheral blood mononuclear cells of multiple sclerosis patients
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abstract
background: multiple sclerosis (ms) is a t cell mediated autoimmune disease with unknown etiology. appropriate ms therapeutic strategies need thorough understanding of both disease etiology and pathogenesis mechanisms. ligation of tlr-2 and tlr-4 stimulates the production of several cytokines leading to cns autoimmunity and neurodegenerative diseases. objective: to find a relationship between ms disability and tlr-2 and tlr-4 expression on mononuclear cells in the blood of ms patients. methods: forty-five new case (nc) ms patients (33 females and 12 males) and 45 age and gender-matched healthy controls (hc) were recruited to the study. pbmcs were prepared and the expressions of tlr-2 and tlr-4 were assessed by flowcytometry technique using appropriate monoclonal antibodies. results: our results showed that the expression of tlr-2 and tlr-4 proteins in the patients group was significantly higher than that of healthy controls. tlr-2 but not tlr-4 was correlated with expanded disability status scale (edss) scores. conclusion: high expressions of tlr-2 and tlr-4 may represent a state of innate immune activation in patients with ms.
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Journal title:
iranian journal of immunologyجلد ۱۱، شماره ۲، صفحات ۷۴-۸۳
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